EFFECT OF MELINJO PEEL EXTRACT ON TRIGLYCERIDES LEVEL OF THE RATS FED A HIGH CHOLESTEROL DIET

Abstract

https://doi.org/10.32827/ijphcs.5.6.301

Background: Hypertriglyceridemia is a risk factor for coronary heart diseases and strokes may be prevented high antioxidant food that found in plants. One of plants that use to prevent this, called Melinjo peel. Melinjo peel contains flavonoid can lower triglyceride levels. The objective of this study is to measure triglyceride levels before and after being given extract of Melinjo peel treatment.

Materials and Methods: The type of research that used in this study is true experimental, by pre-test post-test control group design. High cholesterol diet is given by oral gavage for each of rats as much as 1,8 grams per day. The doses of Melinjo peel extract are given for 54,15 mg/kg, 108,3 mg/kg, and 216,6 mg/kg. Statistical analysis that used is Paired Sample T-Test and MANOVA (Multivariate Analyses of Variance).

Result: Based on statistical analysis, showed that there are differences of triglyceride levels in the high cholesterol diet group, first treatment, second and third treatment before and after treatment significant (p. < 0.05). Levels of triglycerides in the normal diet group compared with the high cholesterol group and third treatment showed a significant difference (p. < 0.05).

Conclusion: Melinjo peel extract can decreased triglyceride levels after treatment, those can be due to the flavonoid, lycopene, and vitamin C of Melinjo peel extract.

Keywords: hypertriglyceridemia, Melinjo peel, flavonoid