RELATIONSHIP OF TRIGLYCERIDES/HIGH DENSITY LIPOPROTEIN-CHOLESTEROL INDEX WITH ANTIOXIDANT DEFENSE AND OUTSTANDING ASSOCIATION WITH HIGH SENSITIVE C-REACTIVE PROTEIN IN MEXICAN SUBJECTS

Abstract

ABSTRACT

Background: The TriGlycerides/High-Density Lipoprotein- Cholesterol (TG/HDL-C) ratio is a new index that has been proposed to estimate CardioVascular Risk (CVR). However, the relationship between this index with the antioxidant defense and inflammation is unknown. The aim of the study was to determine the relationship between the TG/HDL-C index with antioxidant defense and inflammation marker in Mexican subjects.

Materials and Methods: In the study, Mexican subjects participated who were anthropometrically, biochemically, and clinically characterized. The TG/HDL-C index was calculated by dividing TG levels by HDL-C levels; a cut-off point >3 was considered CVR. The study subjects were divided into three groups: 1) subjects without CVR; 2) subjects with CVR, and 3) subjects with Type 2 Diabetes (T2D). In the subjects, we evaluated antioxidant defense by determine SuperOxide Dismutase (SOD) and Glutathione Peroxidase (GPx) activities, and high sensitive C-Reactive Protein (hsCRP) as inflammation marker.                    

Result: A total of 1,491 subjects participated in the study: 553 without CVR; 674 with CVR, and 264 with T2D. It was found that antioxidant defense was diminished in subjects with CVR and with T2D, and that hsCRP levels were increased, in contrast with subjects without CVR (p <0.05). An association between the TG/HDL-C index and hsCRP levels was observed (p <0.01), as well as a correlation with SOD, GPx, and hsCRP levels (p <0.01).

Conclusion: the TG/HDL-C index is related to the inflammatory process through the hsCRP marker and with low antioxidant defense through the correlation found with the activity of enzymes SOD and GPx.

Keywords: TG/HDL-C index, superoxide dismutase, glutathione peroxidase, high sensitive C reactive protein.