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International Journal of Public Health and Clinical Sciences (IJPHCS)
Open Access e-journal ISSN : 2289-7577


Muhamad Hanafiah Juni, Noor Haslinda I.



The burden of tuberculosis is still high despite various strategies implemented to curb the disease. Millions of people diagnosed with tuberculosis every year and more than half of tuberculosis incidence are from India, Indonesia, China, Nigeria, Pakistan and South Africa. Medication adherence become a growing concern of public health. Treatment interruption and poor adherence resulted in treatment failure, prolonged the period of infectiousness and development of drug resistance tuberculosis. Therefore, it is very important to find factors that associated with medication adherence to help improve the tuberculosis control program in general. This article aims to find evidence of various factors that associated with tuberculosis medication adherence among adult patients diagnosed with pulmonary tuberculosis. The selection criteria for considering studies for this review include and not restricted to geographical area, recent article published not more than 5 years and patients diagnosed as pulmonary tuberculosis according to World Health Organization standard. The search engine includes PubMed, Medline and CINAHL with the mesh terms used; [“tuberculosis/TB” AND “adherence/compliance/medication adherence/concordance”]. Total of 9 articles included in the review. Various factors have been linked with medication adherence among pulmonary tuberculosis patients and were divided into patient’s factors, health provider factors, structural or system factors and others. Patients factors that improve adherence to tuberculosis treatment are knowledge pertaining to tuberculosis and its treatment. While, poor motivation to complete the treatment, belief of cured after one or 2 months on treatment and experiencing drug side effects were among the factors that significantly associated with tuberculosis non-adherent. Tobacco smoking, alcohol and drug substances abuse also found to be a risk factor of tuberculosis treatment interruption. Health provider factors such as inadequate drug supply and prolonged waiting time. System or structural factors such as access to healthcare facilities and other related factors are poor social support and underlying human immunodeficiency virus infection. In conclusion, thorough analysis on the factors associated with adherence according to the epidemiological situation and locals’ factors is important to escalate the chances of treatment success among all tuberculosis cases and ultimately ending tuberculosis.

Keywords: tuberculosis, medication adherence

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