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International Journal of Public Health and Clinical Sciences (IJPHCS)
Open Access e-journal ISSN : 2289-7577

EPSTEIN-BARR VIRUS (EBV) AND ITS ASSOCIATION WITH NASOPHARYNGEAL CARCINOMA (NPC): A SYSTEMATIC REVIEW

Sri Ganesh Muthiah, Lye MS

Abstract


ABSTRACT

Introduction: NPC has viral, environmental, and genetic components to its etiology. The involvement of Epstein-Barr Virus (EBV) in NPC has been postulated since the year 1966, when NPC patients were found to express antibodies against an antigen later identified as EBV (Old LJ, Boyse EA and Oettgen HF 1966). EBV infection have been associated with development of several malignancies, including nasopharyngeal carcinoma (IARC; 1997). The latency period usually lasts for several decades before the onset of NPC (Ellen T, Chang and Hans-Olov Adami 2006). Following the discovery of EBV, various studies were undertaken to find an association between the virus and NPC. A systematic review was performed to evaluate the available literature on the relationship between EBV and NPC. 

Data Sources: Systematic review of primary studies identified through MEDLINE, DynaMed, and Cochrane Database. Systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. MEDLINE, EMBASE, and Cochrane databases were queried for English language studies published between 2001 and 2016. 

Results: The initial database from the search performed identified 68 articles, which were screened for relevance to the assessment of EBV and its association with NPC. In addition to these 68 articles, there were 4 other articles, which were identified through other sources. Manual searching of reference lists of the 48 full text articles yielded no additional eligible studies. In total, 49 articles were included for the systematic review. 

Conclusion: The findings of this systematic review suggest an association between Epstein - Barr virus and nasopharyngeal carcinoma. These findings are consistent with the current understanding of the role of EBV as a viral agent in association with the occurrence of NPC. 

Keywords: Epstein - Barr virus, EBV, Nasopharyngeal Carcinoma, NPC

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